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Details on Person UniProt:Q9NPA0 EMC7
| Class:Id | ReferenceGeneProduct:224739 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-242 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NPA0 EMC7 |
| _timestamp | 2024-11-03 20:05:13 |
| chain | signal peptide:1-23 chain:24-242 |
| checksum | A71930B89A4C2458 |
| comment | FUNCTION Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).SUBUNIT Component of the ER membrane protein complex (EMC).INTERACTION Belongs to the EMC7 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Endoplasmic reticulum membrane protein complex subunit 7 alternativeName: ER membrane protein complex subunit 7 |
| geneName | EMC7 C11orf3 C15orf24 HT022 UNQ905/PRO1926 |
| identifier | Q9NPA0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Endoplasmic reticulum Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EMC7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990097] ENSEMBL:ENSG00000134153 EMC7 [Homo sapiens] |
| secondaryIdentifier | EMC7_HUMAN B2RC00 Q96ED5 |
| sequenceLength | 242 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9986516] EMC7 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NPA0 EMC7 (224739)
