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Details on Person UniProt:Q12860-3 CNTN1
| Class:Id | ReferenceIsoform:224705 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21- added on Sat February 7 2015;propeptide:-1018 added on Sat February 7 2015 |
| _displayName | UniProt:Q12860-3 CNTN1 |
| _timestamp | 2024-11-03 19:50:31 |
| chain | signal peptide:1-20 chain:21-993 propeptide:994-1018 |
| checksum | 4B8FDC5BFD434ED5 |
| comment | FUNCTION Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).SUBUNIT Monomer (PubMed:2026173). Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB (By similarity). Interacts with TASOR (By similarity).INTERACTION Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the immunoglobulin superfamily. Contactin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Contactin-1 alternativeName: Glycoprotein gp135 alternativeName: Neural cell surface protein F3 |
| geneName | CNTN1 |
| identifier | Q12860 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell adhesion Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Immunoglobulin domain Lipoprotein Membrane Notch signaling pathway Proteomics identification Reference proteome Repeat Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CNTN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987751] ENSEMBL:ENSG00000018236 CNTN1 [Homo sapiens] |
| secondaryIdentifier | CNTN1_HUMAN A8K0H9 A8K0Y3 Q12861 Q14030 Q7M4P0 Q8N466 |
| sequenceLength | 1018 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q12860-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q12860-3 CNTN1 (224705)
