Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q3UW12 Cnga4
| Class:Id | ReferenceGeneProduct:224623 |
|---|---|
| _chainChangeLog | chain:1-575 added on Fri February 6 2015 |
| _displayName | UniProt:Q3UW12 Cnga4 |
| _timestamp | 2024-08-09 19:00:05 |
| chain | chain:1-575 |
| checksum | 2E79D58D658D4930 |
| comment | FUNCTION Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity) (PubMed:11739959, PubMed:12649326). May conduct nitric oxide-gated Ca(2+) currents relevant to neurons of vomeronasal organ, a system involved in the perception of pheromones (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY NH4(+)(in) = NH4(+)(out)CATALYTIC ACTIVITY Rb(+)(in) = Rb(+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)CATALYTIC ACTIVITY Cs(+)(in) = Cs(+)(out)ACTIVITY REGULATION Ca(2+)-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding.SUBUNIT The olfactory cyclic nucleotide-gated channel is an heterotetramer composed of CNGA2, CNGA4 and CNGB1b subunits with 2:1:1 stoichiometry.SUBCELLULAR LOCATION Expressed in the olfactory epithelium.DOMAIN The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.SIMILARITY Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Cyclic nucleotide-gated channel alpha-4 shortName: CNG channel alpha-4 shortName evidence="10"CNGa4 alternativeName: Olfactory cyclic nucleotide-gated channel subunit 2 shortName evidence="10"OCNC2 |
| geneName | Cnga4 |
| identifier | Q3UW12 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing cAMP cAMP-binding Cell membrane Cell projection Coiled coil Ion channel Ion transport Ligand-gated ion channel Membrane Nucleotide-binding Olfaction Reference proteome Sensory transduction Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Cnga4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CNGA4_MOUSE Q08EL1 |
| sequenceLength | 575 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:224624] UniProt:Q3UW12-2 Cnga4 [Mus musculus] [ReferenceIsoform:406724] UniProt:Q3UW12-1 Cnga4 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9713726] Cnga4 [plasma membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3UW12 Cnga4 (224623)
