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Details on Person UniProt:Q8IV77 CNGA4

Class:Id	ReferenceGeneProduct:224622
_chainChangeLog	chain:1-575 added on Sat February 7 2015
_displayName	UniProt:Q8IV77 CNGA4
_timestamp	2024-11-03 20:18:27
chain	chain:1-575
checksum	4249188A8563A461
comment	FUNCTION Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY NH4(+)(in) = NH4(+)(out)CATALYTIC ACTIVITY Rb(+)(in) = Rb(+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)CATALYTIC ACTIVITY Cs(+)(in) = Cs(+)(out)ACTIVITY REGULATION Ca(2+)-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding.SUBUNIT The olfactory cyclic nucleotide-gated channel is an heterotetramer composed of CNGA2, CNGA4 and CNGB1b subunits with 2:1:1 stoichiometry.SUBCELLULAR LOCATION The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.SIMILARITY Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Cyclic nucleotide-gated channel alpha-4 shortName: CNG channel alpha-4 shortName evidence="9"CNGa4 alternativeName: Olfactory cyclic nucleotide-gated channel subunit 2 shortName evidence="9"OCNC2
geneName	CNGA4
identifier	Q8IV77
isSequenceChanged	FALSE
keyword	Alternative splicing Calcium Calcium channel Calcium transport cAMP cAMP-binding Cell membrane Cell projection cGMP cGMP-binding Coiled coil Ion channel Ion transport Ligand-gated ion channel Membrane Nucleotide-binding Olfaction Proteomics identification Reference proteome Sensory transduction Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	CNGA4
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001691] ENSEMBL:ENSG00000132259 CNGA4 [Homo sapiens]
secondaryIdentifier	CNGA4_HUMAN
sequenceLength	575
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8970943] UniProt:Q8IV77-1 CNGA4 [Homo sapiens] [ReferenceIsoform:8970944] UniProt:Q8IV77-2 CNGA4 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:2671917] CNGA4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624055] CNGA4 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624064] CNGA4 [Golgi-associated vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624069] CNGA4 [ciliary membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q8IV77 CNGA4 (224622)