Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person PDPK1 phosphorylates AKT1 E17K mutant

Class:Id	Reaction:2243942
_displayName	PDPK1 phosphorylates AKT1 E17K mutant
_doRelease	TRUE
_timestamp	2018-11-28 18:54:02
authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2243940] protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer [Disease:1500575] ovarian cancer
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:3080614] gain_of_function of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
input	[Complex:2243941] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain [LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
modified	[InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457743] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3080618] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:9630090] Orlic-Milacic, Marija, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PDPK1 phosphorylates AKT1 E17K mutant
output	[Complex:2219520] PDPK1:PIP2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:2243935] p-T308,S473-AKT1 E17K [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 [Homo sapiens] [Reaction:2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex [Homo sapiens] [Reaction:2219524] PDPK1 binds PIP2 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464994] R-HSA-2243942.3
summation	[Summation:2243936] PIP2-bound AKT1 E17K mutant is constitutively phosphorylated...
(hasEvent)	[Pathway:3080609] Constitutive Signaling by AKT1 E17K Mutant in Cancer [Homo sapiens] [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens]
(precedingEvent)	[Reaction:2399941] AKT1 E17K mutant phosphorylates BAD [Homo sapiens] [Reaction:2399966] AKT1 E17K mutant phosphorylates GSK3 [Homo sapiens] [Reaction:2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 [Homo sapiens] [Reaction:2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) [Homo sapiens] [Reaction:2399981] AKT1 E17K mutant phosphorylates MDM2 [Homo sapiens] [Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it [Homo sapiens] [Reaction:2399985] AKT1 E17K mutant phosphorylates caspase-9 [Homo sapiens] [Reaction:2399997] AKT1 E17K mutant translocates to the nucleus [Homo sapiens] [Reaction:2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by PDPK1 phosphorylates AKT1 E17K mutant (2243942)