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Details on Person AKT1 E17K mutant is phosphorylated by TORC2 complex

Class:Id	Reaction:2243938
_displayName	AKT1 E17K mutant is phosphorylated by TORC2 complex
_doRelease	TRUE
_timestamp	2018-11-28 18:54:01
authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:198624] protein serine/threonine kinase activity of mTORC2:PIP3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1500575] ovarian cancer
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:3080617] gain_of_function of AKT1 E17K mutant:PIP2 [plasma membrane]
input	[Complex:2219527] AKT1 E17K mutant:PIP2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
modified	[InstanceEdit:2317318] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457726] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3080618] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:9630090] Orlic-Milacic, Marija, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant is phosphorylated by TORC2 complex
output	[Complex:2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:2219536] AKT1 E17K mutant binds PIP2 [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464990] R-HSA-2243938.3
summation	[Summation:2243939] PIP2-binding AKT1 E17K mutants are anchored to the plasma m...
(hasEvent)	[Pathway:3080609] Constitutive Signaling by AKT1 E17K Mutant in Cancer [Homo sapiens] [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens]
(precedingEvent)	[Reaction:2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 [Homo sapiens]
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