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Details on Person p-T308,S473-AKT1 E17K [cytosol]

Class:IdEntityWithAccessionedSequence:2243935
_displayNamep-T308,S473-AKT1 E17K [cytosol]
_timestamp2013-06-06 16:42:26
compartment[Compartment:70101] cytosol
created[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
crossReference[DatabaseIdentifier:2219538] COSMIC:COSV62571334
[DatabaseIdentifier:2219535] COSMIC:COSM34142
disease[Disease:1248674] large intestine cancer
[Disease:1500575] ovarian cancer
[Disease:1500576] breast cancer
[Disease:1500689] cancer
endCoordinate480
hasModifiedResidue[ReplacedResidue:1500572] L-glutamic acid 17 replaced with L-lysine
[ModifiedResidue:198374] O-phospho-L-serine at 473
[ModifiedResidue:198329] O-phospho-L-threonine at 308
literatureReference[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
modified[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
namep-T308,S473-AKT1 E17K
referenceEntity[ReferenceGeneProduct:58253] UniProt:P31749 AKT1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2465274] R-HSA-2243935.1
startCoordinate1
(diseaseEntity)[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
(input)[Reaction:2399997] AKT1 E17K mutant translocates to the nucleus [Homo sapiens]
(output)[Reaction:2243942] PDPK1 phosphorylates AKT1 E17K mutant [Homo sapiens]
(physicalEntity)[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
(updatedInstance)[_UpdateTracker:9887425] Update Tracker - [EntityWithAccessionedSequence:2243935] p-T308,S473-AKT1 E17K [cytosol] - v46:[modifyName]
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