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Details on Person UniProt:Q8IUN9 CLEC10A
| Class:Id | ReferenceGeneProduct:224217 |
|---|---|
| _chainChangeLog | chain:1-316 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IUN9 CLEC10A |
| _timestamp | 2025-05-21 21:29:12 |
| chain | chain:1-316 |
| checksum | D3B7193E2E1F58AF |
| comment | FUNCTION C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides (PubMed:15802303, PubMed:23507963). Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions (PubMed:15802303, PubMed:16998493, PubMed:22213806). Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively (PubMed:15802303, PubMed:17616966, PubMed:17804752).SUBUNIT Interacts with A-, B- and C-domain containing PTPRC/CD45 isoforms: isoform 1/CD45ABC, isoform 3/CD45AB, isoform 5/CD45BC and isoform 7/CD45B. Does not interact with PTPRC/CD45 isoform 2/CD45RO, a memory T cell marker.INTERACTION Recycles between the plasma membrane and the endolysosomal compartment. Upon antigen binding, internalizes via endocytosis and then dissociates from antigen at acidic pH characteristic of endolysosomal vesicles.ALTERNATIVE PRODUCTS Expressed in myeloid antigen presenting cells in lymph nodes and skin (at protein level). Expressed in dermal dendritic cells (at protein level).ONLINE INFORMATION MGL |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: C-type lectin domain family 10 member A alternativeName: C-type lectin superfamily member 14 alternativeName: fullName evidence="14"DC-asialoglycoprotein receptor shortName evidence="14"DC-ASGPR alternativeName: fullName evidence="13"Macrophage galactose-type lectin shortName evidence="13"MGL alternativeName: Macrophage lectin 2 cdAntigenName evidence="15"CD301/cdAntigenName |
| geneName | CLEC10A CLECSF13 CLECSF14 HML |
| identifier | Q8IUN9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing Cell membrane Coiled coil Disulfide bond Endocytosis Endosome Glycoprotein Immunity Innate immunity Lectin Lysosome Membrane Proteomics identification Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | CLEC10A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992365] ENSEMBL:ENSG00000132514 CLEC10A [Homo sapiens] |
| secondaryIdentifier | CLC10_HUMAN A8K8J8 Q14538 Q6PIW3 |
| sequenceLength | 316 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:224218] UniProt:Q8IUN9-2 CLEC10A [Homo sapiens] [ReferenceIsoform:224219] UniProt:Q8IUN9-3 CLEC10A [Homo sapiens] [ReferenceIsoform:410785] UniProt:Q8IUN9-1 CLEC10A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1472863] CLEC10A [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IUN9 CLEC10A (224217)
