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Details on Person UniProt:O75122 CLASP2
| Class:Id | ReferenceGeneProduct:224210 |
|---|---|
| _chainChangeLog | chain:1-1294 added on Fri February 6 2015 |
| _displayName | UniProt:O75122 CLASP2 |
| _timestamp | 2024-11-03 20:09:21 |
| chain | chain:1-1294 |
| checksum | EAD31F728BC63B4B |
| comment | FUNCTION Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.SUBUNIT Interacts with microtubules (PubMed:11290329, PubMed:15631994, PubMed:15955847, PubMed:26003921). Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends (PubMed:15631994, PubMed:19632184, PubMed:26003921). Interacts with CLIP2, ERC1, MAPRE3, PHLDB2 and RSN (PubMed:11290329, PubMed:15631994). The interaction with ERC1 may be mediated by PHLDB2 (PubMed:16824950). Interacts with GCC2; recruits CLASP2 to Golgi membranes (PubMed:17543864). Interacts with MACF1 (By similarity). Interacts with mtcl2 and MTCL1 (PubMed:33587225).INTERACTION Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950). Colocalizes with KANK1 at the cell cortex, likely recruited in cortical microtubule stabilization complexes (CMSC) at focal adhesions rims (PubMed:27410476). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.ALTERNATIVE PRODUCTS Additional isoforms exist.TISSUE SPECIFICITY Brain-specific.DOMAIN The two SXIP sequence motifs mediate interaction with MAPRE1; this is necessary for targeting to growing microtubule plus ends.DOMAIN Two TOG regions display structural characteristics similar to HEAT repeat domains and mediate interaction with microtubules.PTM Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.SIMILARITY Belongs to the CLASP family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: CLIP-associating protein 2 alternativeName: Cytoplasmic linker-associated protein 2 alternativeName: Protein Orbit homolog 2 shortName: hOrbit2 |
| geneName | CLASP2 KIAA0627 |
| identifier | O75122 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Cell membrane Cell projection Centromere Chromosome Cytoplasm Cytoskeleton Golgi apparatus Kinetochore Membrane Microtubule Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLASP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997634] ENSEMBL:ENSG00000163539 CLASP2 [Homo sapiens] |
| secondaryIdentifier | CLAP2_HUMAN B2RTR1 F5H604 Q7L8F6 Q8N6R6 Q9BQT3 Q9BQT4 Q9H7A3 Q9NSZ2 |
| sequenceLength | 1294 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:224211] UniProt:O75122-2 CLASP2 [Homo sapiens] [ReferenceIsoform:401813] UniProt:O75122-1 CLASP2 [Homo sapiens] [ReferenceIsoform:8970433] UniProt:O75122-3 CLASP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:376252] CLASP2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75122 CLASP2 (224210)
