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Details on Person UniProt:Q9UID3 VPS51
| Class:Id | ReferenceGeneProduct:223911 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-782 added on Sat February 7 2015;initiator methionine:1 for 223911 removed on Fri Nov 03 2023;initiator methionine: for 223911 added on Fri Nov 03 2023;initiator methionine: for 223911 removed on Fri Aug 15 2025;initiator methionine:1 for 223911 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9UID3 VPS51 |
| _timestamp | 2025-08-15 22:05:27 |
| chain | initiator methionine:1 chain:2-782 |
| checksum | 0E858672E4C656DD |
| comment | FUNCTION Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).SUBUNIT Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:20685960, PubMed:27440922, PubMed:30624672). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061, PubMed:27440922, PubMed:30624672). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (PubMed:27440922). Interacts with STX6 (via N-terminus) (PubMed:20685960). Interacts with VPS50 and VPS54 in an EIPR1-independent manner (PubMed:31721635).INTERACTION Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).ALTERNATIVE PRODUCTS The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the VPS51 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Vacuolar protein sorting-associated protein 51 homolog alternativeName: Another new gene 2 protein alternativeName: Protein fat-free homolog |
| geneName | VPS51 ANG2 C11orf2 C11orf3 FFR PP5382 |
| identifier | Q9UID3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Disease variant Endosome Golgi apparatus Intellectual disability Lipid transport Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VPS51 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989310] ENSEMBL:ENSG00000149823 VPS51 [Homo sapiens] |
| secondaryIdentifier | VPS51_HUMAN Q6PJV5 Q7L8A6 Q8WZ35 Q96DF4 Q96GR3 |
| sequenceLength | 782 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:223912] UniProt:Q9UID3-2 VPS51 [Homo sapiens] [ReferenceIsoform:415396] UniProt:Q9UID3-1 VPS51 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6811027] VPS51 [trans-Golgi network membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UID3 VPS51 (223911)
