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Details on Person UniProt:Q96MA6-2 AK8
| Class:Id | ReferenceIsoform:223638 |
|---|---|
| _chainChangeLog | chain:1-479 added on Fri February 6 2015 |
| _displayName | UniProt:Q96MA6-2 AK8 |
| _timestamp | 2024-11-03 19:51:48 |
| chain | chain:1-479 |
| checksum | 9E4EABA3F429B731 |
| comment | FUNCTION Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.CATALYTIC ACTIVITY AMP + ATP = 2 ADPCATALYTIC ACTIVITY a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADPCATALYTIC ACTIVITY a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADPBIOPHYSICOCHEMICAL PROPERTIES Interacts with CFAP45 and CFAP52; CFAP45 and AK8 dimerization may create a cavity at the interface of the dimer that can accommodate AMP.INTERACTION Located in the proximal region of respiratory cilia.ALTERNATIVE PRODUCTS Expressed in respiratory cells (at protein level).SIMILARITY Belongs to the adenylate kinase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Adenylate kinase 8 shortName: AK 8 ecNumber evidence="2"2.7.4.3 ecNumber evidence="2 3"2.7.4.6 alternativeName: ATP-AMP transphosphorylase 8 |
| geneName | AK8 C9orf98 |
| identifier | Q96MA6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Cell projection Cytoplasm Cytoskeleton Kinase Nucleotide-binding Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AK8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990196] ENSEMBL:ENSG00000165695 AK8 [Homo sapiens] |
| secondaryIdentifier | KAD8_HUMAN A8K821 Q8N9W9 |
| sequenceLength | 479 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96MA6-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96MA6-2 AK8 (223638)
