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Details on Person UniProt:Q7LGC8 CHST3
| Class:Id | ReferenceGeneProduct:223484 |
|---|---|
| _chainChangeLog | chain:1-479 added on Fri February 6 2015 |
| _displayName | UniProt:Q7LGC8 CHST3 |
| _timestamp | 2025-02-21 19:26:20 |
| chain | chain:1-479 |
| checksum | 7C290DC4970F66E0 |
| comment | FUNCTION Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:15215498, PubMed:9714738, PubMed:9883891). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9714738). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:9714738). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity).CATALYTIC ACTIVITY chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.SUBCELLULAR LOCATION Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.PTM N-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="13"Carbohydrate sulfotransferase 3 ecNumber evidence="6 9 10"2.8.2.17 ecNumber evidence="9"2.8.2.21 alternativeName: Chondroitin 6-O-sulfotransferase 1 shortName: C6ST-1 alternativeName: fullName evidence="11"Chondroitin 6-sulfotransferase shortName evidence="11"C6ST alternativeName: Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 shortName: GST-0 |
| geneName | CHST3 |
| identifier | Q7LGC8 |
| isSequenceChanged | FALSE |
| keyword | Carbohydrate metabolism Disease variant Glycoprotein Golgi apparatus Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CHST3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991182] ENSEMBL:ENSG00000122863 CHST3 [Homo sapiens] |
| secondaryIdentifier | CHST3_HUMAN O75099 Q52M30 |
| sequenceLength | 479 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1971541] CHST3 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636785] CHST3 R222W [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636788] CHST3 R304Q [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636789] CHST3 L259P [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636822] CHST3 E372K [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636831] CHST3 L286P [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636832] CHST3 L307P [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:3636860] CHST3 Y201* [Golgi membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:3636782] L-arginine 304 replaced with L-glutamine [ReplacedResidue:3636799] L-arginine 222 replaced with L-tryptophan [ReplacedResidue:3636815] L-leucine 307 replaced with L-proline [ReplacedResidue:3636830] L-glutamic acid 372 replaced with L-lysine [NonsenseMutation:3636847] Nonsense mutation at L-tyrosine 201 [ReplacedResidue:3636859] L-leucine 286 replaced with L-proline [ReplacedResidue:3636865] L-leucine 259 replaced with L-proline |
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No pathways have been reviewed or authored by UniProt:Q7LGC8 CHST3 (223484)
