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Details on Person UniProt:O43916 CHST1
| Class:Id | ReferenceGeneProduct:223478 |
|---|---|
| _chainChangeLog | chain:1-411 added on Fri February 6 2015 |
| _displayName | UniProt:O43916 CHST1 |
| _timestamp | 2024-11-03 19:35:40 |
| chain | chain:1-411 |
| checksum | F07D0A23B6338A09 |
| comment | FUNCTION Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:10642612, PubMed:17690104, PubMed:9405439). Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (PubMed:9405439). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:10330415). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (PubMed:10642612).CATALYTIC ACTIVITY 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.BIOPHYSICOCHEMICAL PROPERTIES Glycan metabolism.INTERACTION Widely expressed at low level. Expressed in brain and skeletal muscle. Expressed by high endothelial cells (HEVs) and leukocytes.SIMILARITY Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.CAUTION Was originally (PubMed:9639683) thought to be the ortholog of chicken CHST3 and therefore named C6ST. However, it has no strong chondroitin 6-sulfotransferase activity. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Carbohydrate sulfotransferase 1 alternativeName: Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1 shortName: GST-1 alternativeName: Keratan sulfate Gal-6 sulfotransferase shortName: KS6ST shortName: KSGal6ST shortName: KSST ecNumber evidence="7 8"2.8.2.21 |
| geneName | CHST1 |
| identifier | O43916 |
| isSequenceChanged | FALSE |
| keyword | Carbohydrate metabolism Glycoprotein Golgi apparatus Inflammatory response Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CHST1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002259] ENSEMBL:ENSG00000175264 CHST1 [Homo sapiens] |
| secondaryIdentifier | CHST1_HUMAN D3DQP2 |
| sequenceLength | 411 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1971540] CHST1 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43916 CHST1 (223478)
