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Details on Person UniProt:Q9BRQ6 CHCHD6
| Class:Id | ReferenceGeneProduct:223365 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-235 added on Sat February 7 2015;initiator methionine:1 for 223365 removed on Fri Nov 03 2023;initiator methionine: for 223365 added on Fri Nov 03 2023;initiator methionine: for 223365 removed on Fri Aug 15 2025;initiator methionine:1 for 223365 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BRQ6 CHCHD6 |
| _timestamp | 2025-08-15 21:54:26 |
| chain | initiator methionine:1 chain:2-235 |
| checksum | 674DE387557AF4F0 |
| comment | FUNCTION Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.SUBUNIT Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:17624330, PubMed:22228767, PubMed:25781180, PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1 (PubMed:22228767). Interacts with DISC1 (PubMed:22228767). Interacts with IMMT/MIC60 (PubMed:22228767, PubMed:25997101).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus protein UL37 isoform vMIA; this interaction rewires mitochondria by engaging the conserved MICOS complex.INTERACTION Down-regulated following genotoxic stress.SIMILARITY Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: MICOS complex subunit MIC25 alternativeName: Coiled-coil-helix cristae morphology protein 1 alternativeName: Coiled-coil-helix-coiled-coil-helix domain-containing protein 6 |
| geneName | CHCHD6 CHCM1 MIC25 |
| identifier | Q9BRQ6 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Disulfide bond Host-virus interaction Lipoprotein Membrane Mitochondrion Mitochondrion inner membrane Myristate Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CHCHD6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962177] ENSEMBL:ENSG00000159685 CHCHD6 [Homo sapiens] |
| secondaryIdentifier | MIC25_HUMAN D6R9U0 D6RIB4 H8Y0Y7 |
| sequenceLength | 235 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8949568] CHCHD6 (MIC25) [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BRQ6 CHCHD6 (223365)
