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Details on Person UniProt:Q9GZY4 COA1
| Class:Id | ReferenceGeneProduct:223199 |
|---|---|
| _chainChangeLog | chain:1-146 added on Sat February 7 2015 |
| _displayName | UniProt:Q9GZY4 COA1 |
| _timestamp | 2024-11-03 20:18:29 |
| chain | chain:1-146 |
| checksum | 24582046A282291C |
| comment | FUNCTION Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV (PubMed:23260140). As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I (PubMed:32320651).SUBUNIT Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COX17 and COA6. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186 (PubMed:32320651).SUBCELLULAR LOCATION Belongs to the COA1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="5"Cytochrome c oxidase assembly factor 1 homolog alternativeName: Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa |
| geneName | COA1 C7orf44 MITRAC15 |
| identifier | Q9GZY4 |
| isSequenceChanged | FALSE |
| keyword | Membrane Mitochondrion Mitochondrion inner membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | COA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998233] ENSEMBL:ENSG00000106603 COA1 [Homo sapiens] |
| secondaryIdentifier | COA1_HUMAN A6NJU8 A8KAH8 Q9HAB7 Q9NVD2 |
| sequenceLength | 146 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9708001] COA1 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9GZY4 COA1 (223199)
