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Details on Person UniProt:Q8IW35 CEP97
| Class:Id | ReferenceGeneProduct:222928 |
|---|---|
| _chainChangeLog | chain:1-865 added on Sat February 7 2015 |
| _displayName | UniProt:Q8IW35 CEP97 |
| _timestamp | 2024-11-03 19:35:37 |
| chain | chain:1-865 |
| checksum | 98B1C230DF586DF7 |
| comment | FUNCTION Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545).SUBUNIT Interacts with CALM1, CEP76, KIF24 and TALPID3. Interacts with CCP110. ENKD1 competes with CEP97 for binding to CCP110, destabilizing the interaction between CP110 and CEP97 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (By similarity). Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4 (PubMed:22261722). Interacts with MPHOSPH9 (PubMed:30375385).INTERACTION Recruited at the distal end of the mother centriole by MPHOSPH9.ALTERNATIVE PRODUCTS Sequence incomplete.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Centrosomal protein of 97 kDa shortName: Cep97 alternativeName: Leucine-rich repeat and IQ domain-containing protein 2 |
| geneName | CEP97 LRRIQ2 |
| identifier | Q8IW35 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calmodulin-binding Cilium biogenesis/degradation Cytoplasm Cytoskeleton Leucine-rich repeat Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CEP97 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962488] ENSEMBL:ENSG00000182504 CEP97 [Homo sapiens] |
| secondaryIdentifier | CEP97_HUMAN B5MDY8 Q8NA71 Q9H5T9 |
| sequenceLength | 865 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:222929] UniProt:Q8IW35-2 CEP97 [Homo sapiens] [ReferenceIsoform:410830] UniProt:Q8IW35-1 CEP97 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5626440] CEP97 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IW35 CEP97 (222928)
