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Details on Person UniProt:Q9P209 CEP72
| Class:Id | ReferenceGeneProduct:222918 |
|---|---|
| _chainChangeLog | chain:1-647 added on Fri February 6 2015 |
| _displayName | UniProt:Q9P209 CEP72 |
| _timestamp | 2024-11-03 19:40:20 |
| chain | chain:1-647 |
| checksum | 9F45C88511311460 |
| comment | FUNCTION Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).SUBUNIT Interacts with KIZ, PCM1 and CDK5RAP2.INTERACTION Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.ALTERNATIVE PRODUCTS Belongs to the CEP72 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Centrosomal protein of 72 kDa shortName: Cep72 |
| geneName | CEP72 KIAA1519 |
| identifier | Q9P209 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Cytoskeleton Leucine-rich repeat Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CEP72 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998800] ENSEMBL:ENSG00000112877 CEP72 [Homo sapiens] |
| secondaryIdentifier | CEP72_HUMAN B4DR26 Q9BV03 Q9BWM3 Q9NVR4 |
| sequenceLength | 647 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:436021] UniProt:Q9P209-1 CEP72 [Homo sapiens] [ReferenceIsoform:436022] UniProt:Q9P209-2 CEP72 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:380321] CEP72 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9P209 CEP72 (222918)
