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Details on Person UniProt:Q71F23 CENPU
| Class:Id | ReferenceGeneProduct:222879 |
|---|---|
| _chainChangeLog | chain:1-418 added on Sat February 7 2015 |
| _displayName | UniProt:Q71F23 CENPU |
| _timestamp | 2024-11-03 20:18:21 |
| chain | chain:1-418 |
| checksum | A99BC012EF7188F9 |
| comment | FUNCTION Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.SUBUNIT Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with MLF1. Interacts with PLK1.SUBUNIT (Microbial infection) Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LNA).INTERACTION Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.ALTERNATIVE PRODUCTS Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.PTM Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.SIMILARITY Belongs to the CENP-U/AME1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Centromere protein U shortName: CENP-U alternativeName: Centromere protein of 50 kDa shortName: CENP-50 alternativeName: Interphase centromere complex protein 24 alternativeName: KSHV latent nuclear antigen-interacting protein 1 alternativeName: MLF1-interacting protein alternativeName: Polo-box-interacting protein 1 |
| geneName | CENPU ICEN24 KLIP1 MLF1IP PBIP1 |
| identifier | Q71F23 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Centromere Chromosome Coiled coil Cytoplasm Host-virus interaction Isopeptide bond Kinetochore Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CENPU |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999388] ENSEMBL:ENSG00000151725 CENPU [Homo sapiens] |
| secondaryIdentifier | CENPU_HUMAN A2RRD9 Q09GN2 Q32Q71 Q9H5G1 |
| sequenceLength | 418 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:222880] UniProt:Q71F23-2 CENPU [Homo sapiens] [ReferenceIsoform:409062] UniProt:Q71F23-1 CENPU [Homo sapiens] [ReferenceIsoform:8975921] UniProt:Q71F23-3 CENPU [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375315] MLF1IP [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:606309] MLF1IP [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q71F23 CENPU (222879)
