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Details on Person UniProt:Q96BT3 CENPT
| Class:Id | ReferenceGeneProduct:222873 |
|---|---|
| _chainChangeLog | chain:1-561 added on Fri February 6 2015 |
| _displayName | UniProt:Q96BT3 CENPT |
| _timestamp | 2024-11-03 20:13:41 |
| chain | chain:1-561 |
| checksum | 295848C52AAF7DF1 |
| comment | FUNCTION Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.SUBUNIT Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622419, PubMed:19412974, PubMed:19533040). Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:19412974, PubMed:21695110, PubMed:27499292). Interacts (via N-terminus) with the NDC80 complex (Probable). Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:19070575, PubMed:19533040, PubMed:21529714, PubMed:21695110, PubMed:22304917).INTERACTION Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus.ALTERNATIVE PRODUCTS The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.PTM Dynamically phosphorylated at Ser-47 and probably also other sites during the cell cycle. Phosphorylated at Ser-47 during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CENP-T/CNN1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Centromere protein T shortName: CENP-T alternativeName: Interphase centromere complex protein 22 |
| geneName | CENPT C16orf56 ICEN22 |
| identifier | Q96BT3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome DNA-binding Dwarfism Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CENPT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001068] ENSEMBL:ENSG00000102901 CENPT [Homo sapiens] |
| secondaryIdentifier | CENPT_HUMAN Q96I29 Q96IC6 Q96NK9 Q9H901 |
| sequenceLength | 561 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:222874] UniProt:Q96BT3-2 CENPT [Homo sapiens] [ReferenceIsoform:222875] UniProt:Q96BT3-3 CENPT [Homo sapiens] [ReferenceIsoform:412667] UniProt:Q96BT3-1 CENPT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375316] CENPT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5633498] CENPT [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96BT3 CENPT (222873)
