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Details on Person UniProt:Q96FF9 CDCA5
| Class:Id | ReferenceGeneProduct:222533 |
|---|---|
| _chainChangeLog | chain:1-252 added on Sat February 7 2015 |
| _displayName | UniProt:Q96FF9 CDCA5 |
| _timestamp | 2024-11-03 19:35:33 |
| chain | chain:1-252 |
| checksum | A4CD6768D3464040 |
| comment | FUNCTION Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.SUBUNIT Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPL.INTERACTION Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.DOMAIN The KEN box is required for the association with the APC/C complex.PTM Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.PTM Ubiquitinated by the APC/C complex in G1, leading to its degradation.MISCELLANEOUS Named sororin after the Latin word 'soror', which means 'sister', because of its critical role in sister chromatid cohesion.SIMILARITY Belongs to the sororin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Sororin alternativeName: Cell division cycle-associated protein 5 alternativeName: p35 |
| geneName | CDCA5 |
| identifier | Q96FF9 |
| isSequenceChanged | FALSE |
| keyword | Cell cycle Cell division Chromosome Cytoplasm Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDCA5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987728] ENSEMBL:ENSG00000146670 CDCA5 [Homo sapiens] |
| secondaryIdentifier | CDCA5_HUMAN A8K625 |
| sequenceLength | 252 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2466357] CDCA5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2468149] CDCA5 [chromosome] [Homo sapiens] [EntityWithAccessionedSequence:2468260] CDCA5 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2468266] p-S21,S75,T159-CDCA5 [chromosome] [Homo sapiens] [EntityWithAccessionedSequence:2468269] p-S21,S75,T159-CDCA5 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2484804] p-S21,S75,T159-CDCA5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2484891] CDCA5 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2468265] O-phospho-L-threonine at 159 [ModifiedResidue:2468267] O-phospho-L-serine at 75 [ModifiedResidue:2468270] O-phospho-L-serine at 21 |
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No pathways have been reviewed or authored by UniProt:Q96FF9 CDCA5 (222533)
