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Details on Person UniProt:Q8VCN6 Cd99
Class:Id
ReferenceGeneProduct:222491
_chainChangeLog
signal peptide:1-28 added on Sat February 7 2015;chain:29-175 added on Sat February 7 2015
_displayName
UniProt:Q8VCN6 Cd99
_timestamp
2025-05-21 21:17:19
chain
signal peptide:1-28 chain:29-175
checksum
A309E6E2494FBFE1
comment
FUNCTION Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.SUBUNIT Homodimer. Interacts with PILRB.SUBCELLULAR LOCATION Widely expressed with high levels in lung, spleen, thymus, liver and spinal cord. Expressed on leukocytes and endothelial cell contacts. Detected in a wide range of T-cells, including CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in peripheral T-cells than in thymocytes.SIMILARITY Belongs to the CD99 family.
