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Details on Person UniProt:Q96EA4 SPDL1
| Class:Id | ReferenceGeneProduct:222221 |
|---|---|
| _chainChangeLog | chain:1-605 added on Fri February 6 2015 |
| _displayName | UniProt:Q96EA4 SPDL1 |
| _timestamp | 2026-02-20 23:11:40 |
| chain | chain:1-605 |
| checksum | 1F8D38C9261D6605 |
| comment | FUNCTION Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100).SUBUNIT Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect (PubMed:19468067). Interacts with dynein intermediate chain and dynactin (DCTN1) (PubMed:25035494). Interacts with the catalytically active form of USP45 (PubMed:30258100).INTERACTION Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.ALTERNATIVE PRODUCTS Monoubiquitinated with'Lys-48' linkage (PubMed:30258100). Deubiquitinated by USP45 (PubMed:30258100).SIMILARITY Belongs to the Spindly family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="2"Protein Spindly shortName: hSpindly alternativeName: Arsenite-related gene 1 protein alternativeName: fullName evidence="2"Coiled-coil domain-containing protein 99 alternativeName: Rhabdomyosarcoma antigen MU-RMS-40.4A alternativeName: fullName evidence="2"Spindle apparatus coiled-coil domain-containing protein 1 |
| geneName | SPDL1 CCDC99 |
| identifier | Q96EA4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Centromere Chromosome Coiled coil Cytoplasm Cytoskeleton Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SPDL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003250] ENSEMBL:ENSG00000040275 SPDL1 [Homo sapiens] |
| secondaryIdentifier | SPDLY_HUMAN B4E393 C9JS47 Q8TEC8 Q9HD44 Q9NX97 |
| sequenceLength | 605 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:222222] UniProt:Q96EA4-2 SPDL1 [Homo sapiens] [ReferenceIsoform:412723] UniProt:Q96EA4-1 SPDL1 [Homo sapiens] [ReferenceIsoform:8977629] UniProt:Q96EA4-3 SPDL1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:377733] SPDL1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96EA4 SPDL1 (222221)
