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Details on Person NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding

Class:Id	Reaction:2220976
_displayName	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
_doRelease	TRUE
_timestamp	2018-11-29 14:48:43
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:1852619] metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
disease	[Disease:1500689] cancer [Disease:1485587] T-cell acute lymphoblastic leukemia
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:9630138] gain_of_function of NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
entityOnOtherCell	[DefinedSet:2902211] NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] [Homo sapiens]
input	[DefinedSet:2902212] NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:2691227] Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
modified	[InstanceEdit:2223328] Orlic-Milacic, M, 2012-05-03 [InstanceEdit:2223329] Orlic-Milacic, M, 2012-05-03 [InstanceEdit:2289140] Orlic-Milacic, M, 2012-05-28 [InstanceEdit:2289148] Orlic-Milacic, M, 2012-05-28 [InstanceEdit:2902224] Orlic-Milacic, M, 2013-01-03 [InstanceEdit:2902227] Orlic-Milacic, M, 2013-01-03 [InstanceEdit:2916617] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2916618] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2923416] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2930213] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2981030] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:4532351] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:9630139] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
output	[DefinedSet:2289143] NEXT1 PEST domain mutants [plasma membrane] [Homo sapiens] [DefinedSet:2902211] NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2900765] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200188] R-HSA-2220976.3
summation	[Summation:2902226] NOTCH1 HD domain mutants are cleaved at S2 and S3 sites to p...
(hasEvent)	[Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(precedingEvent)	[Reaction:2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (2220976)