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Details on Person CDK8 phosphorylates NICD1 PEST domain mutants

Class:Id	Reaction:2220971
_displayName	CDK8 phosphorylates NICD1 PEST domain mutants
_doRelease	TRUE
_timestamp	2015-08-05 19:35:55
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:2220956] cyclin-dependent protein serine/threonine kinase activity of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775819] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:2220980] NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
modified	[InstanceEdit:2769020] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2775828] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2851307] Orlic-Milacic, M, 2012-12-13 [InstanceEdit:2916618] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2981026] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:2981030] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:6789899] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK8 phosphorylates NICD1 PEST domain mutants
normalReaction	[Reaction:1912391] NICD1 is phosphorylated by CDK8 [Homo sapiens]
output	[Complex:1911412] RBPJ:SNW1 [nucleoplasm] [Homo sapiens] [Complex:1604465] CDK8:CCNC [nucleoplasm] [Homo sapiens] [CandidateSet:212357] MAML [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [CandidateSet:350078] PCAF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens] [DefinedSet:2220958] p-NICD1 PEST domain mutants [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2220957] NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC [Homo sapiens] [Reaction:2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200232] R-HSA-2220971.3
summation	[Summation:2851296] While CDK8 can probably phosphorylate the TAD domain of NICD...
(hasEvent)	[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens] [Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(precedingEvent)	[FailedReaction:2220967] p-NICD1 PEST domain mutants do not bind FBXW7 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784042] Update Tracker - [Reaction:2220971] CDK8 phosphorylates NICD1 PEST domain mutants - v54:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by CDK8 phosphorylates NICD1 PEST domain mutants (2220971)