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Details on Person NOTCH1 PEST domain mutants stimulate HES5 transcription

Class:Id	BlackBoxEvent:2220966
_displayName	NOTCH1 PEST domain mutants stimulate HES5 transcription
_doRelease	TRUE
_timestamp	2015-08-05 19:35:58
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:4396399] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm]
input	[EntityWithAccessionedSequence:2197557] HES5 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1911382] Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
modified	[InstanceEdit:2769019] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2775828] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2851307] Orlic-Milacic, M, 2012-12-13 [InstanceEdit:3095961] Orlic-Milacic, M, 2013-02-08 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:4396389] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4396407] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:6789899] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 PEST domain mutants stimulate HES5 transcription
normalReaction	[BlackBoxEvent:1980078] NOTCH1 stimulates HES5 transcription [Homo sapiens]
output	[EntityWithAccessionedSequence:1606739] HES5 [nucleoplasm] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:2220983] Positive gene expression regulation by 'NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm]'
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200661] R-HSA-2220966.4
summation	[Summation:2851295] NICD1 PEST domain mutants are expected to stimulate HES5 tra...
(hasEvent)	[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens] [Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784524] Update Tracker - [BlackBoxEvent:2220966] NOTCH1 PEST domain mutants stimulate HES5 transcription - v54:[addLiteratureReference, modifyText] [_UpdateTracker:9787066] Update Tracker - [BlackBoxEvent:2220966] NOTCH1 PEST domain mutants stimulate HES5 transcription - v46:[addInput, add_removeRegulator]
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No pathways have been reviewed or authored by NOTCH1 PEST domain mutants stimulate HES5 transcription (2220966)