Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

Class:Id	Reaction:2220964
_displayName	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
_doRelease	TRUE
_timestamp	2015-08-05 19:35:56
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775822] gain_of_function of NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]
input	[CandidateSet:212357] MAML [nucleoplasm] [Homo sapiens] [CandidateSet:350078] PCAF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens] [Complex:2220969] NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:351538] Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex [LiteratureReference:2064894] p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro [LiteratureReference:208099] Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
modified	[InstanceEdit:2769019] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2775828] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2851307] Orlic-Milacic, M, 2012-12-13 [InstanceEdit:2916618] Orlic-Milacic, M, 2013-01-04 [InstanceEdit:2981028] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:2981030] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:6789899] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
normalReaction	[Reaction:1912394] NICD1 in complex with RBPJ (CSL) recruits MAML [Homo sapiens]
output	[Complex:2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) [Homo sapiens] [Reaction:2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200698] R-HSA-2220964.3
summation	[Summation:2851302] NICD1 PEST domain mutants in complex with RBPJ and SNW1 are ...
(hasEvent)	[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens] [Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(precedingEvent)	[Reaction:2220957] NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC [Homo sapiens] [Reaction:4396392] NOTCH1 PEST domain mutants bind HES1 promoter [Homo sapiens] [Reaction:4396393] NOTCH1 PEST domain mutants bind MYC promoter [Homo sapiens] [Reaction:4396401] NOTCH1 PEST domain mutants bind HES5 promoter [Homo sapiens] [Reaction:4396402] NOTCH1 PEST domain mutants bind promoters of HEY genes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784124] Update Tracker - [Reaction:2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML - v54:[addLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (2220964)