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Details on Person NOTCH1 HD domain mutants [plasma membrane]

Class:Id	CandidateSet:2220961
_displayName	NOTCH1 HD domain mutants [plasma membrane]
_timestamp	2013-02-28 11:17:55
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
hasCandidate	[Complex:2681760] NOTCH1 L1574P [plasma membrane] [Homo sapiens] [Complex:2681765] NOTCH1 L1600P [plasma membrane] [Homo sapiens] [Complex:2691204] NOTCH1 L1574Q [plasma membrane] [Homo sapiens]
hasMember	[Complex:2684844] NOTCH1 V1576E [plasma membrane] [Homo sapiens] [Complex:2684856] NOTCH1 F1592S [plasma membrane] [Homo sapiens] [Complex:2681757] NOTCH1 L1593P [plasma membrane] [Homo sapiens] [Complex:2684851] NOTCH1 L1596H [plasma membrane] [Homo sapiens] [Complex:2681756] NOTCH1 R1598P [plasma membrane] [Homo sapiens] [Complex:2684861] NOTCH1 I1616N [plasma membrane] [Homo sapiens] [Complex:2684867] NOTCH1 I1616T [plasma membrane] [Homo sapiens] [Complex:2684873] NOTCH1 V1676D [plasma membrane] [Homo sapiens] [Complex:2681761] NOTCH1 L1678P [plasma membrane] [Homo sapiens] [Complex:2684871] NOTCH1 I1680N [plasma membrane] [Homo sapiens] [Complex:2681758] NOTCH1 A1701P [plasma membrane] [Homo sapiens] [Complex:2684883] NOTCH1 I1718T [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:2681766] Orlic-Milacic, M, 2012-11-28 [InstanceEdit:2684859] Orlic-Milacic, M, 2012-11-30 [InstanceEdit:2684885] Orlic-Milacic, M, 2012-11-30 [InstanceEdit:2691228] Orlic-Milacic, M, 2012-12-03
name	NOTCH1 HD domain mutants NOTCH1 heterodimerization domain mutants
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3201770] R-HSA-2220961.1
(diseaseEntity)	[EntityFunctionalStatus:2711103] gain_of_function of NOTCH1 HD domain mutants [plasma membrane] [EntityFunctionalStatus:9631997] gain_of_function of NOTCH1 HD domain mutants [plasma membrane]
(hasComponent)	[Complex:2691215] JAG1:NOTCH1 HD domain mutants [plasma membrane] [Homo sapiens] [Complex:2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane] [Homo sapiens] [Complex:2691218] JAG2:NOTCH1 HD domain mutants [plasma membrane] [Homo sapiens] [Complex:2691221] DLL4:NOTCH1 HD domain mutants [plasma membrane] [Homo sapiens]
(hasMember)	[CandidateSet:2289142] NOTCH1 HD mutants/t(7;9)(q34;q34.3) translocation mutant [plasma membrane] [Homo sapiens] [DefinedSet:2717729] NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] [Homo sapiens]
(input)	[Reaction:2691211] NOTCH1 HD domain mutants bind DLL4 [Homo sapiens] [Reaction:2691214] NOTCH1 HD domain mutants bind JAG2 [Homo sapiens] [Reaction:2691219] NOTCH1 HD domain mutants bind DLL1 [Homo sapiens] [Reaction:2691226] NOTCH1 HD domain mutants bind JAG1 [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH1 HD domain mutants [plasma membrane] (2220961)