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Details on Person UniProt:O60729-3 CDC14B
| Class:Id | ReferenceIsoform:221874 |
|---|---|
| _chainChangeLog | chain:1-498 added on Fri February 6 2015 |
| _displayName | UniProt:O60729-3 CDC14B |
| _timestamp | 2025-02-21 19:26:00 |
| chain | chain:1-498 |
| checksum | CEE15EC4DC3B1DC7 |
| comment | FUNCTION Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateSUBUNIT Interacts with FZR1/CDH1.INTERACTION Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.ALTERNATIVE PRODUCTS Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Dual specificity protein phosphatase CDC14B ecNumber: 3.1.3.16 ecNumber: 3.1.3.48 alternativeName: CDC14 cell division cycle 14 homolog B |
| geneName | CDC14B |
| identifier | O60729 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing DNA damage DNA repair Hydrolase Nucleus Protein phosphatase Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CDC14B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997614] ENSEMBL:ENSG00000081377 CDC14B [Homo sapiens] |
| secondaryIdentifier | CC14B_HUMAN A6N5X8 A8MQ20 B1AL31 B1AL32 O43183 O60730 Q5JU08 |
| sequenceLength | 498 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O60729-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60729-3 CDC14B (221874)
