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Details on Person UniProt:Q9H0I3 CFAP263
| Class:Id | ReferenceGeneProduct:221765 |
|---|---|
| _chainChangeLog | chain:1-377 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H0I3 CFAP263 |
| _timestamp | 2025-08-15 22:15:40 |
| chain | chain:1-377 |
| checksum | 6375CDF98733E33B |
| comment | FUNCTION Component of centriolar satellites contributing to primary cilium formation (PubMed:25074808). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity).SUBUNIT Forms a complex with CFAP184; the interaction is required for functional activity in cilia (By similarity). Interacts with HAP1 and PCM1 (PubMed:25074808).INTERACTION Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1 (PubMed:25074808). Localizes at cilium but not at the ciliary tips (By similarity).ALTERNATIVE PRODUCTS Belongs to the CFAP263 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="5"Cilia- and flagella-associated protein 263 |
| geneName | CFAP263 CCDC113 HSPC065 |
| identifier | Q9H0I3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell projection Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CFAP263 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000494] ENSEMBL:ENSG00000103021 CFAP263 [Homo sapiens] |
| secondaryIdentifier | CF263_HUMAN B2RAQ7 B4DR20 Q9NZX2 |
| sequenceLength | 377 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973673] UniProt:Q9H0I3-1 CFAP263 [Homo sapiens] [ReferenceIsoform:8973674] UniProt:Q9H0I3-2 CFAP263 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9967061] CFAP263 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969169] CFAP263 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H0I3 CFAP263 (221765)
