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Details on Person UniProt:Q69ZR9 Tasor
| Class:Id | ReferenceGeneProduct:221719 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1610 added on Fri February 6 2015;initiator methionine:1 for 221719 removed on Fri Nov 03 2023;initiator methionine: for 221719 added on Fri Nov 03 2023;initiator methionine: for 221719 removed on Fri Aug 15 2025;initiator methionine:1 for 221719 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q69ZR9 Tasor |
| _timestamp | 2026-02-20 21:54:43 |
| chain | initiator methionine:1 chain:2-1610 |
| checksum | B8DDF5E02905CE9F |
| comment | FUNCTION Core component of the HUSH complex, a multiprotein complex that specifically mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (By similarity). The HUSH complex represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (By similarity). The HUSH complex also represses exogenous retroviruses and synthetic transgenes (By similarity). Mediates silencing of unintegrated retroviral DNA following recruitment by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). Within the HUSH complex, TASOR acts as the central scaffold which recruits MPHOSPH8 and PPHLN1 to mobile genetic elements and mediates association with SETDB1 and MORC2 (By similarity). The ability to silence mobile genetic elements plays a crucial role in early embryonic development: it is required to maintain epiblast cell fitness and cell division (PubMed:24781204, PubMed:28839193, PubMed:31112734).SUBUNIT Core component of the HUSH complex, also named HUSH1 complex, composed of TASOR, PPHLN1 and MPHOSPH8 (By similarity). Interacts with MORC2; recruiting MORC2 to heterochromatic loci (By similarity). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (By similarity). Interacts with INPP5A, EML1, SV1L, GPSM2, ITGB3BP, CNTN1, ETFA, PSMD8, S100A10, MPHOSPH8, TMEM100, ALB, PARPBP, HCFC2, NCBP1 and SETDB1 (PubMed:31112734).SUBCELLULAR LOCATION Localizes to chromatin.ALTERNATIVE PRODUCTS Present in skin, brain and testis (at protein level) (PubMed:24781204). Ubiquitously expressed at low levels in the majority of the organs, expressed at higher levels in kidneys, spleen, thymus, seminal vesicles, uterus, and ovaries and its expression is almost six times higher in male tissues than in females (PubMed:31112734). Highly expressed in seminiferous tubules with a strong signal in Sertoli cells, spermatogonia, and spermatocytes (PubMed:31112734).DEVELOPMENTAL STAGE Expressed in the epiblast at 5.5 dpc, expression extends into the extraembryonic ectoderm at 6.5 dpc, and at 7.5 dpc expressed in embryonic ectoderm, allantois, amnion and chorion. From 8.5 to 9.5 dpc, ubiquitously expressed in the developing embryo.DOMAIN The TASOR pseudo-PARP domain is essential for the repression of mobile genetic elements.DISRUPTION PHENOTYPE Embryonic lethality with robust developmentally delayed phenotype observed at 8.5 dpc, progressing through 9.5 dpc with full lethality by 12.5 dpc (PubMed:24781204, PubMed:28839193). RNAi-mediated knockdown in zygotes results in formation of multipolar spindles and increased ratio of arrested or incorrectly developed embryos (PubMed:28839193).SIMILARITY Belongs to the TASOR family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="9"Protein TASOR alternativeName: fullName evidence="1"Transgene activation suppressor protein |
| geneName | Tasor D14Abb1e Fam208a Kiaa1105 |
| identifier | Q69ZR9 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Chromosome Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Tasor |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TASOR_MOUSE E9PUH2 Q9CUD3 |
| sequenceLength | 1610 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:8976274] UniProt:Q69ZR9-1 Tasor [Mus musculus] [ReferenceIsoform:8976275] UniProt:Q69ZR9-2 Tasor [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9843982] Tasor [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q69ZR9 Tasor (221719)
