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Details on Person UniProt:Q9UK61 TASOR
| Class:Id | ReferenceGeneProduct:221715 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-1670 added on Sat February 7 2015;initiator methionine:1 for 221715 removed on Fri Nov 03 2023;initiator methionine: for 221715 added on Fri Nov 03 2023;initiator methionine: for 221715 removed on Fri Aug 15 2025;initiator methionine:1 for 221715 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9UK61 TASOR |
| _timestamp | 2026-02-20 21:54:42 |
| chain | initiator methionine:1 chain:2-1670 |
| checksum | A8BE5ED05A96C897 |
| comment | FUNCTION Core component of the HUSH complex, a multiprotein complex that specifically mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (PubMed:26022416, PubMed:28581500, PubMed:29211708, PubMed:32976585, PubMed:33009411, PubMed:37433650). The HUSH complex represses LINE-1 (L1) retrotransposons that are still capable of transposition (PubMed:29211708, PubMed:32976585). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex also represses exogenous retroviruses and synthetic transgenes (PubMed:26022416). The HUSH complex also represses expression of latent herpes simplex virus (PubMed:39589886). Mediates silencing of unintegrated retroviral DNA following recruitment by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (PubMed:26022416, PubMed:28581500). Within the HUSH complex, TASOR acts as the central scaffold which recruits MPHOSPH8 and PPHLN1 to mobile genetic elements and mediates association with SETDB1 and MORC2 (PubMed:32976585, PubMed:33009411, PubMed:39589886). The ability to silence mobile genetic elements plays a crucial role in early embryonic development: it is required to maintain epiblast cell fitness and cell division (By similarity).SUBUNIT Core component of the HUSH complex, also named HUSH1 complex, composed of TASOR, PPHLN1 and MPHOSPH8 (PubMed:26022416, PubMed:32976585, PubMed:39013473, PubMed:39489739). Interacts with MORC2; recruiting MORC2 to heterochromatic loci (PubMed:28581500). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (PubMed:30487602). Interacts with INPP5A, EML1, SV1L, GPSM2, ITGB3BP, CNTN1, ETFA, PSMD8, S100A10, MPHOSPH8, TMEM100, ALB, PARPBP, HCFC2, NCBP1 and SETDB1 (By similarity).INTERACTION Localizes to chromatin.ALTERNATIVE PRODUCTS The TASOR pseudo-PARP domain is essential for the repression of mobile genetic elements.PTM (Microbial infection) Ubiquitinated following interaction with HIV-2 viral protein Vpx; Vpx promotes interaction and with a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase, leading to proteasomal degradation.SIMILARITY Belongs to the TASOR family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="22"Protein TASOR alternativeName: fullName evidence="19"CTCL tumor antigen se89-1 alternativeName: fullName evidence="21"Retinoblastoma-associated protein RAP140 alternativeName: fullName evidence="22"Transgene activation suppressor protein |
| geneName | TASOR C3orf63 FAM208A KIAA1105 |
| identifier | Q9UK61 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosome Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TASOR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989258] ENSEMBL:ENSG00000163946 TASOR [Homo sapiens] |
| secondaryIdentifier | TASOR_HUMAN A1L3A4 B5ME28 Q9H2F7 Q9UPP7 |
| sequenceLength | 1670 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:221716] UniProt:Q9UK61-2 TASOR [Homo sapiens] [ReferenceIsoform:221717] UniProt:Q9UK61-3 TASOR [Homo sapiens] [ReferenceIsoform:221718] UniProt:Q9UK61-4 TASOR [Homo sapiens] [ReferenceIsoform:415438] UniProt:Q9UK61-1 TASOR [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9844031] TASOR [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UK61 TASOR (221715)
