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Details on Person Antigen presenting cells (APCs) such as B cells, dendritic c...
| Class:Id | Summation:2216754 |
|---|---|
| _displayName | Antigen presenting cells (APCs) such as B cells, dendritic c... |
| _timestamp | 2012-05-03 15:09:47 |
| created | [InstanceEdit:2216757] Garapati, P V, 2012-05-01 |
| literatureReference | [LiteratureReference:2216756] Presentation of cytosolic antigens via MHC class II molecules [LiteratureReference:2216755] The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules [LiteratureReference:2130329] MHC II and the endocytic pathway: regulation by invariant chain [LiteratureReference:2216752] MHC class II transport at a glance |
| modified | [InstanceEdit:2220950] Jupe, S, 2012-05-03 |
| text | Antigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exogenous antigenic peptides to CD4+ T helper cells. CD4+ T cells play a central role in immune protection. On their activation they stimulate differentiation of B cells into antibody-producing B-cell blasts and initiate adaptive immune responses. MHC class II molecules are transmembrane glycoprotein heterodimers of alpha and beta subunits. Newly synthesized MHC II molecules present in the endoplasmic reticulum bind to a chaperone protein called invariant (Ii) chain. The binding of Ii prevents the premature binding of self antigens to the nascent MHC molecules in the ER and also guides MHC molecules to endocytic compartments. In the acidic endosomal environment, Ii is degraded in a stepwise manner, ultimately to free the class II peptide-binding groove for loading of antigenic peptides. Exogenous antigens are internalized by the APC by receptor mediated endocytosis, phagocytosis or pinocytosis into endocytic compartments of MHC class II positive cells, where engulfed antigens are degraded in a low pH environment by multiple acidic proteases, generating MHC class II epitopes. Antigenic peptides are then loaded into the class II ligand-binding groove. The resulting class II peptide complexes then move to the cell surface, where they are scanned by CD4+ T cells for specific recognition (Berger & Roche 2009, Zhou & Blum 2004, Watts 2004, Landsverk et al. 2009). |
| (summation) | [Pathway:2132295] MHC class II antigen presentation [Homo sapiens] |
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No pathways have been reviewed or authored by Antigen presenting cells (APCs) such as B cells, dendritic c... (2216754)
