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Details on Person UniProt:Q9DAG5 Stpg4
| Class:Id | ReferenceGeneProduct:221503 |
|---|---|
| _chainChangeLog | chain:1-247 added on Fri February 6 2015 |
| _displayName | UniProt:Q9DAG5 Stpg4 |
| _timestamp | 2024-08-09 20:02:12 |
| chain | chain:1-247 |
| checksum | 5A9BBD78EE7BD9FA |
| comment | FUNCTION Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote (PubMed:23560077, PubMed:28930672). Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:23560077, PubMed:28930672).SUBUNIT Interacts with histone H3 (PubMed:23560077). Interacts with histone H4 (PubMed:23560077). Interacts with METTL23 (PubMed:28930672).SUBCELLULAR LOCATION Localizes in female and male zygote pronucleus (PubMed:16571911, PubMed:23560077). Associates preferentially with the paternal chromatin during zygote development (PubMed:23560077).TISSUE SPECIFICITY Expressed in ovary and testis (PubMed:16571911). Expressed in spermatocytes I in the pachytene stage, round spermatids, and elongated spermatids (PubMed:16571911). Expressed in the germinal vesicle (GV) stage and stage 2 meiosis (MII) oocytes and pre-implantation embryos until blastocyst stage (at protein level) (PubMed:16571911, PubMed:23560077).DISRUPTION PHENOTYPE No visible phenotype (PubMed:28930672). Mice were born at the expected Mendelian ratio and show no overt phenotype (PubMed:28930672). Zygotes however display strongly reduced levels of 5-hydroxymethylcytosine (5hmC) (PubMed:28930672). |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="5"Protein STPG4 alternativeName: fullName evidence="4"Gonad-specific expression gene protein shortName evidence="4"GSE alternativeName: fullName evidence="6"Sperm-tail PG-rich repeat-containing protein 4 |
| geneName | Stpg4 |
| identifier | Q9DAG5 |
| isSequenceChanged | FALSE |
| keyword | Chromatin regulator Cytoplasm Developmental protein Nucleus Reference proteome |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Stpg4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | STPG4_MOUSE |
| sequenceLength | 247 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9822611] Stpg4 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9DAG5 Stpg4 (221503)
