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Details on Person UniProt:Q96MC2 DRC1
| Class:Id | ReferenceGeneProduct:221447 |
|---|---|
| _chainChangeLog | chain:1-740 added on Fri February 6 2015 |
| _displayName | UniProt:Q96MC2 DRC1 |
| _timestamp | 2026-02-20 22:08:50 |
| chain | chain:1-740 |
| checksum | 3CBF68B32B441C22 |
| comment | FUNCTION Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:23354437, PubMed:34169321). Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437).SUBUNIT Component of the nexin-dynein regulatory complex (N-DRC). Interacts with DRC2, DRC3, DRC4 and DRC5 (PubMed:34169321).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the DRC1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Dynein regulatory complex protein 1 alternativeName: Coiled-coil domain-containing protein 164 |
| geneName | DRC1 C2orf39 CCDC164 |
| identifier | Q96MC2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection Ciliopathy Cilium Coiled coil Cytoplasm Cytoskeleton Disease variant Flagellum Primary ciliary dyskinesia Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DRC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997124] ENSEMBL:ENSG00000157856 DRC1 [Homo sapiens] |
| secondaryIdentifier | DRC1_HUMAN A8K1N8 Q53R91 Q53TA3 Q8NDI5 |
| sequenceLength | 740 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9962988] DRC1 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969333] DRC1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96MC2 DRC1 (221447)
