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Details on Person PLK1 phosphorylates GORASP1
Class:Id Reaction:2214351 _displayName PLK1 phosphorylates GORASP1 _doRelease TRUE _timestamp 2023-03-17 21:39:18 authored [InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23 catalystActivity [CatalystActivity:2214352] protein serine/threonine kinase activity of p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane] compartment [Compartment:20699] Golgi membrane [Compartment:70101] cytosol created [InstanceEdit:2214350] Orlic-Milacic, M, 2012-04-30 edited [InstanceEdit:162660] Gillespie, ME, 2005-04-04 01:40:57 figure [Figure:162989] /figures/polokinases_GRASP65.jpg input [SimpleEntity:113592] ATP [cytosol] [Complex:2172193] p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane] [Homo sapiens] literatureReference [LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2314408] Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand [LiteratureReference:162958] Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis [LiteratureReference:2463812] A direct role for GRASP65 as a mitotically regulated Golgi stacking factor modified [InstanceEdit:2314418] Orlic-Milacic, M, 2012-06-07 [InstanceEdit:2314572] Orlic-Milacic, M, 2012-06-07 [InstanceEdit:2422396] Orlic-Milacic, M, 2012-07-18 [InstanceEdit:2422966] Orlic-Milacic, M, 2012-07-19 [InstanceEdit:2426698] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457822] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463849] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463853] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463868] Orlic-Milacic, M, 2012-08-31 [InstanceEdit:2466353] Matthews, L, 2012-09-07 [InstanceEdit:2466354] Matthews, L, 2012-09-07 [InstanceEdit:2507814] Orlic-Milacic, M, 2012-10-04 [InstanceEdit:2660809] D'Eustachio, P, 2012-11-23 [InstanceEdit:9032153] Orlic-Milacic, Marija, 2017-12-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9831004] D'Eustachio, Peter, 2023-03-17 name PLK1 phosphorylates GORASP1 output [SimpleEntity:29370] ADP [cytosol] [Complex:2314414] p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1 [Golgi membrane] [Homo sapiens] precedingEvent
releaseDate 2005-04-11 reviewed [InstanceEdit:2463852] Wang, Yanzhuang, 2012-08-19 [InstanceEdit:2463846] Colanzi, Antonino, 2012-08-21 [InstanceEdit:2507813] Malhotra, Vivek, 2012-08-15 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:2424242] Orlic-Milacic, M, 2012-07-20 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2465013] R-HSA-2214351.3 summation [Summation:2314560] CDK1-mediated phosphorylation of GORASP1 (GRASP65) enables G... (hasEvent) [Pathway:162658] Golgi Cisternae Pericentriolar Stack Reorganization [Homo sapiens] (precedingEvent) [BlackBoxEvent:2314566] GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking [Homo sapiens] (updatedInstance) [_UpdateTracker:9788178] Update Tracker - [Reaction:2214351] PLK1 phosphorylates GORASP1 - v43:[modifyText]
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