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Details on Person Disassociation of CLIP from MHC II

Class:Id	Reaction:2213246
_displayName	Disassociation of CLIP from MHC II
_doRelease	TRUE
_timestamp	2012-05-31 09:47:52
authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
compartment	[Compartment:17938] lysosomal membrane [Compartment:161320] lysosomal lumen
created	[InstanceEdit:2213245] Garapati, P V, 2012-04-30
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
input	[Complex:2130574] MHC II:CLIP [lysosomal membrane] [Homo sapiens] [DefinedSet:2213230] HLA-DM/HLA-DO [lysosomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2213147] Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH [LiteratureReference:2213175] Self-release of CLIP in peptide loading of HLA-DR molecules [LiteratureReference:2213161] Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding [LiteratureReference:2213170] HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH [LiteratureReference:2213151] Negative regulation by HLA-DO of MHC class II-restricted antigen processing [LiteratureReference:2213177] A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules [LiteratureReference:2213124] The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
modified	[InstanceEdit:2247929] Garapati, P V, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Disassociation of CLIP from MHC II
output	[Complex:2213227] peptide free MHC II:HLA-DM [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:2213220] CD74(81-104) [lysosomal lumen] [Homo sapiens]
precedingEvent	[Reaction:2130349] Generation of CLIP from lip10 [Homo sapiens] [Reaction:2130504] Cleavage of lip22 to lip10 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295061] R-HSA-2213246.2
summation	[Summation:2213091] To gain the capacity to activate antigen-specific T cells, M...
(hasEvent)	[Pathway:2132295] MHC class II antigen presentation [Homo sapiens]
(precedingEvent)	[Reaction:2213244] Loading of antigenic peptides [Homo sapiens]
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No pathways have been reviewed or authored by Disassociation of CLIP from MHC II (2213246)