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Details on Person Loading of antigenic peptides

Class:Id	Reaction:2213244
_displayName	Loading of antigenic peptides
_doRelease	TRUE
_timestamp	2026-04-27 18:36:43
authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:2213245] Garapati, P V, 2012-04-30
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
input	[Complex:2213227] peptide free MHC II:HLA-DM [lysosomal membrane] [Homo sapiens] [OtherEntity:2213226] MHC class II epitopes [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2213173] Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide [LiteratureReference:2213138] Editing of the HLA-DR-peptide repertoire by HLA-DM [LiteratureReference:2213145] Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM [LiteratureReference:2213130] Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM [LiteratureReference:2213124] The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
modified	[InstanceEdit:2247929] Garapati, P V, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	Loading of antigenic peptides
output	[Complex:2213223] peptide loaded MHC class II [lysosomal membrane] [Homo sapiens] [DefinedSet:2213230] HLA-DM/HLA-DO [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:2130706] MHC class II antigen processing [Homo sapiens] [Reaction:2213240] Reduction of disulphide bonds in MHC II antigens [Homo sapiens] [Reaction:2213246] Disassociation of CLIP from MHC II [Homo sapiens] [Reaction:2130349] Generation of CLIP from lip10 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294705] R-HSA-2213244.3
summation	[Summation:2213105] In the acidic compartments of MIICs the empty MHC II molecul...
(hasEvent)	[Pathway:2132295] MHC class II antigen presentation [Homo sapiens] [Pathway:9979719] Processing of antigen in germinal center B cells [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:2213248] Transport of antigen loaded MHC II molecules to surface [Homo sapiens]
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No pathways have been reviewed or authored by Loading of antigenic peptides (2213244)