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Details on Person UniProt:Q86VP6 CAND1

Class:Id	ReferenceGeneProduct:221237
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-1230 added on Fri February 6 2015;initiator methionine:1 for 221237 removed on Fri Nov 03 2023;initiator methionine: for 221237 added on Fri Nov 03 2023;initiator methionine: for 221237 removed on Fri Aug 15 2025;initiator methionine:1 for 221237 added on Fri Aug 15 2025
_displayName	UniProt:Q86VP6 CAND1
_timestamp	2025-08-15 21:51:35
chain	initiator methionine:1 chain:2-1230
checksum	FE344558F72D79D8
comment	FUNCTION Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.SUBUNIT Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with ERCC6 (PubMed:26030138). Interacts with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions are bridged by cullins and strongly inhibits the neddylation of cullins (PubMed:24192928, PubMed:25349211, PubMed:26906416).INTERACTION Predominantly cytoplasmic.ALTERNATIVE PRODUCTS Repressed by miR-148a.MISCELLANEOUS A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate' deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).SIMILARITY Belongs to the CAND family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Cullin-associated NEDD8-dissociated protein 1 alternativeName: Cullin-associated and neddylation-dissociated protein 1 alternativeName: TBP-interacting protein of 120 kDa A shortName: TBP-interacting protein 120A alternativeName: p120 CAND1
geneName	CAND1 KIAA0829 TIP120 TIP120A
identifier	Q86VP6
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	CAND1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958083] ENSEMBL:ENSG00000111530 CAND1 [Homo sapiens]
secondaryIdentifier	CAND1_HUMAN B2RAU3 O94918 Q6PIY4 Q8NDJ4 Q96JZ9 Q96T19 Q9BTC4 Q9H0G2 Q9P0H7 Q9UF85
sequenceLength	1230
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:221238] UniProt:Q86VP6-2 CAND1 [Homo sapiens] [ReferenceIsoform:221239] UniProt:Q86VP6-3 CAND1 [Homo sapiens] [ReferenceIsoform:409881] UniProt:Q86VP6-1 CAND1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5691146] CAND1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6801390] CAND1 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801399] CAND1 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801558] CAND1 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806498] CAND1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8955089] CAND1 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q86VP6 CAND1 (221237)