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Details on Person UniProt:Q969V5 MUL1
| Class:Id | ReferenceGeneProduct:220941 |
|---|---|
| _chainChangeLog | chain:1-352 added on Sat February 7 2015 |
| _displayName | UniProt:Q969V5 MUL1 |
| _timestamp | 2026-02-20 23:08:02 |
| chain | chain:1-352 |
| checksum | 6EF2B8BBFCE1801F |
| comment | FUNCTION Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation (PubMed:22410793). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:18207745, PubMed:18213395, PubMed:19407830). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (PubMed:23399697). Can mediate RIGI sumoylation and disrupt its polyubiquitination (PubMed:23399697).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.PATHWAY Protein modification; protein sumoylation.SUBUNIT Homooligomer (PubMed:18591963). Interacts with MAP3K7/TAK1 (PubMed:18591963). Interacts with UBC9 (PubMed:19407830). Interacts with and sumoylates DNM1L (PubMed:19407830). Interacts with MAVS (PubMed:23399697, PubMed:40105103). Interacts with TP53 (via N-terminus); the interaction leads to ubiquitination and proteasomal degradation of TP53 (PubMed:21597459). Interacts with ABCB10, BAG6, CCDC51, MTCH1, MTCH2 and TRABD (PubMed:40105103). Interacts with TOM complex (PubMed:40105103).INTERACTION Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.TISSUE SPECIFICITY Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.DOMAIN The zinc finger domain is required for E3 ligase activity.PTM Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Mitochondrial ubiquitin ligase activator of NFKB 1 ecNumber evidence="5 7 8"2.3.2.27 alternativeName: E3 SUMO-protein ligase MUL1 alternativeName: E3 ubiquitin-protein ligase MUL1 alternativeName: Growth inhibition and death E3 ligase alternativeName: Mitochondrial-anchored protein ligase alternativeName: fullName evidence="13"Protein Hades alternativeName: Putative NF-kappa-B-activating protein 266 alternativeName: RING finger protein 218 alternativeName: fullName evidence="14"RING-type E3 ubiquitin transferase NFKB 1 |
| geneName | MUL1 C1orf166 GIDE MAPL MULAN RNF218 |
| identifier | Q969V5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Apoptosis Isopeptide bond Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Peroxisome Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MUL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004822] ENSEMBL:ENSG00000090432 MUL1 [Homo sapiens] |
| secondaryIdentifier | MUL1_HUMAN B5M497 Q7Z431 Q9H9B5 |
| sequenceLength | 352 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2993772] MUL1 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783184] PolyUb-MUL1 [mitochondrial outer membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783164] ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q969V5 MUL1 (220941)
