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Details on Person UniProt:Q6NZ36 FAAP20

Class:Id	ReferenceGeneProduct:220735
_chainChangeLog	chain:1-180 added on Fri February 6 2015
_displayName	UniProt:Q6NZ36 FAAP20
_timestamp	2026-02-20 22:54:25
chain	chain:1-180
checksum	D8FC889A20AF732F
comment	FUNCTION Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.SUBUNIT Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts (via UBZ2-type zinc finger) with REV1; this interaction contributes to the stable association of the two proteins in nuclear foci in response to replication stress. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823).INTERACTION Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.ALTERNATIVE PRODUCTS The UBZ2-type zinc finger binds both 'Lys-48'- and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.CAUTION According to a report, ubiquitin-binding is dispensable for function (PubMed:22396592). However, such data are not confirmed by PubMed:22705371.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="15"Fanconi anemia core complex-associated protein 20 alternativeName: fullName evidence="10"FANCA-associated protein of 20 kDa alternativeName: fullName evidence="10"Fanconi anemia-associated protein of 20 kDa
geneName	FAAP20 C1orf86 FP7162
identifier	Q6NZ36
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Chromosome DNA damage DNA repair Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	FAAP20
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999479] ENSEMBL:ENSG00000162585 FAAP20 [Homo sapiens]
secondaryIdentifier	FAP20_HUMAN A6PW39 A6PW40 A6PW41 A8MQT6 F2Z2L4 Q6ZT64 Q71M24 Q96ND7
sequenceLength	180
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:220736] UniProt:Q6NZ36-2 FAAP20 [Homo sapiens] [ReferenceIsoform:220737] UniProt:Q6NZ36-3 FAAP20 [Homo sapiens] [ReferenceIsoform:220738] UniProt:Q6NZ36-4 FAAP20 [Homo sapiens] [ReferenceIsoform:220739] UniProt:Q6NZ36-5 FAAP20 [Homo sapiens] [ReferenceIsoform:408373] UniProt:Q6NZ36-1 FAAP20 [Homo sapiens] [ReferenceIsoform:8975107] UniProt:Q6NZ36-6 FAAP20 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:6783321] FAAP20 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9835400] FAAP20 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q6NZ36 FAAP20 (220735)