Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q5T440 IBA57
| Class:Id | ReferenceGeneProduct:220704 |
|---|---|
| _chainChangeLog | transit peptide:1-39 added on Sat February 7 2015;chain:40-356 added on Sat February 7 2015 |
| _displayName | UniProt:Q5T440 IBA57 |
| _timestamp | 2025-08-15 21:59:14 |
| chain | transit peptide:1-39 chain:40-356 |
| checksum | 199A04DAB6840807 |
| comment | FUNCTION Mitochondrial protein involved in the maturation of mitochondrial [4Fe-4S]-proteins in the late stage of the iron-sulfur cluster assembly pathway (PubMed:22323289, PubMed:23462291). Operates in cooperation with ISCA2 in the maturation of [4Fe-4S] proteins (PubMed:30269484).FUNCTION Involved in the maturation of mitochondrial 2Fe-2S proteins in the late stage of the iron-sulfur cluster assembly pathway.SUBUNIT Monomer (PubMed:31831856). Heterotetramer; forms a dimer of dimers with ISCA2 (PubMed:31831856). Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation (PubMed:30269484).INTERACTION Expressed in skin fibroblasts and skeletal muscle (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GcvT family. CAF17/IBA57 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Iron-sulfur cluster assembly factor IBA57, mitochondrial alternativeName: Iron-sulfur cluster assembly factor homolog |
| geneName | IBA57 C1orf69 |
| identifier | Q5T440 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Disease variant Heme biosynthesis Hereditary spastic paraplegia Mitochondrion Neurodegeneration Primary mitochondrial disease Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | IBA57 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987711] ENSEMBL:ENSG00000181873 IBA57 [Homo sapiens] |
| secondaryIdentifier | CAF17_HUMAN |
| sequenceLength | 356 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5691205] IBA57 [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5T440 IBA57 (220704)
