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Details on Person UniProt:Q6IQ49 SDE2
| Class:Id | ReferenceGeneProduct:220674 |
|---|---|
| _chainChangeLog | chain:1-451 added on Fri February 6 2015 |
| _displayName | UniProt:Q6IQ49 SDE2 |
| _timestamp | 2024-11-03 19:38:46 |
| chain | propeptide:1-77 chain:78-451 |
| checksum | D7C19152E0051A21 |
| comment | FUNCTION Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959).FUNCTION Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity).FUNCTION Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507).SUBUNIT Interacts (via PIP-box) with PCNA; the interaction is direct and prevents ultraviolet light induced monoubiquitination of PCNA (PubMed:27906959). Interacts with FBL/fibrillarin (PubMed:34365507). Interacts with CACTIN (PubMed:34365507). Interacts with SF3B1 (PubMed:34365507). Interacts with U2AF1 (PubMed:34365507).INTERACTION Ubiquitously expressed; enriched in brain, lung and liver.DOMAIN The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.DOMAIN The SAP domain is necessary for specific binding to DNA.DOMAIN The propeptide displays a ubiquitin-like fold.PTM Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner.PTM Both SDE2-UBL and the mature SDE2 are polyubiquitinated.SIMILARITY Belongs to the SDE2 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="10"Splicing regulator SDE2 alternativeName: fullName evidence="10"Replication stress response regulator SDE2 |
| geneName | SDE2 C1orf55 |
| identifier | Q6IQ49 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Coiled coil Cytoplasm DNA replication DNA-binding Mitosis mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Ribosome biogenesis RNA-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SDE2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996869] ENSEMBL:ENSG00000143751 SDE2 [Homo sapiens] |
| secondaryIdentifier | SDE2_HUMAN A8K4P3 Q5TD36 Q6ZS26 Q8NAG7 |
| sequenceLength | 451 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:220675] UniProt:Q6IQ49-2 SDE2 [Homo sapiens] [ReferenceIsoform:220676] UniProt:Q6IQ49-3 SDE2 [Homo sapiens] [ReferenceIsoform:408260] UniProt:Q6IQ49-1 SDE2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9769593] SDE2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q6IQ49 SDE2 (220674)
