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Details on Person Endocytosis of TRAM (TICAM2)

Class:IdReaction:2201341
_displayNameEndocytosis of TRAM (TICAM2)
_doReleaseTRUE
_timestamp2016-06-22 21:00:46
authored[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
compartment[Compartment:74700] endosome membrane
[Compartment:876] plasma membrane
created[InstanceEdit:2201342] Shamovsky, V, 2012-04-19
edited[InstanceEdit:2272804] Shamovsky, V, 2012-05-25
input[EntityWithAccessionedSequence:166160] MyrG-p-S16-TICAM2 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:975473] Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling
[LiteratureReference:975477] TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
[LiteratureReference:2206266] Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
[LiteratureReference:8877178] Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM
modified[InstanceEdit:2206272] Shamovsky, V, 2012-04-26
[InstanceEdit:2248850] Shamovsky, V, 2012-05-15
[InstanceEdit:2272807] Shamovsky, V, 2012-05-25
[InstanceEdit:2272824] Shamovsky, V, 2012-05-25
[InstanceEdit:2279180] Shamovsky, V, 2012-05-28
[InstanceEdit:2581523] Shamovsky, V, 2012-11-13
[InstanceEdit:3621899] Shamovsky, V, 2013-05-24
[InstanceEdit:8877508] Orlic-Milacic, Marija, 2016-06-22
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEndocytosis of TRAM (TICAM2)
output[EntityWithAccessionedSequence:2201336] MyrG-p-S16-TICAM2 [endosome membrane] [Homo sapiens]
regulatedBy[NegativeRegulation:8877176] Negative regulation by 'PTPN4 [cytosol]'
regulationReference[RegulationReference:9641901] Negative regulation by 'PTPN4 [cytosol]' Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM
releaseDate2012-06-12
reviewed[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25
[InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2295117] R-HSA-2201341.5
summation[Summation:2206263] TRIF-related adapter molecule (TRAM or also known as TICAM2)...
(hasEvent)[Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782829] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v58:[addLiteratureReference, addRegulator, modifyText]
[_UpdateTracker:9787319] Update Tracker - [Reaction:2201341] Endocytosis of TRAM (TICAM2) - v45:[modifyText]
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No pathways have been reviewed or authored by Endocytosis of TRAM (TICAM2) (2201341)
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