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Details on Person TRAF3 binds TICAM1:activated TLR4 complex

Class:Id	Reaction:2201338
_displayName	TRAF3 binds TICAM1:activated TLR4 complex
_doRelease	TRUE
_timestamp	2017-07-26 05:52:14
authored	[InstanceEdit:2206372] Shamovsky, V, 2012-04-26
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:2201337] Shamovsky, V, 2012-04-19
edited	[InstanceEdit:2272804] Shamovsky, V, 2012-05-25
input	[EntityWithAccessionedSequence:914241] TRAF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:914241] TRAF3 [cytosol] [Homo sapiens] [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:1216473] Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
modified	[InstanceEdit:2213022] Shamovsky, V, 2012-04-27 [InstanceEdit:2248851] Shamovsky, V, 2012-05-15 [InstanceEdit:2272824] Shamovsky, V, 2012-05-25 [InstanceEdit:2279180] Shamovsky, V, 2012-05-28 [InstanceEdit:2299706] Shamovsky, V, 2012-06-01 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632486] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5483109] Shamovsky, V, 2014-05-16 [InstanceEdit:9013875] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF3 binds TICAM1:activated TLR4 complex TRAF3 binds TRIF:activated TLR4 complex TRAF3 binds TICAM1:TRAM:TLR4:LY96:LPS:CD14
output	[Complex:2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) [Homo sapiens]
regulatedBy	[NegativeRegulation:2559577] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2012-06-12
reviewed	[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294970] R-HSA-2201338.4
summation	[Summation:2213011] Tumor necrosis factor (TNF) receptor associated factor 3 (TR...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:2213017] Auto-ubiquitination of TRAF3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780816] Update Tracker - [Reaction:2201338] TRAF3 binds TICAM1:activated TLR4 complex - v62:[add_removeInput, modifyText] [_UpdateTracker:9788142] Update Tracker - [Reaction:2201338] TRAF3 binds TICAM1:activated TLR4 complex - v43:[addRegulator, modifyText] [_UpdateTracker:9842350] Update Tracker - [Reaction:2201338] TRAF3 binds TICAM1:activated TLR4 complex - v86:[modifyText]
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No pathways have been reviewed or authored by TRAF3 binds TICAM1:activated TLR4 complex (2201338)