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Details on Person TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]

Class:IdComplex:2201331
_displayNameTIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]
_timestamp2018-08-09 02:31:11
compartment[Compartment:876] plasma membrane
created[InstanceEdit:2201327] Shamovsky, V, 2012-04-19
hasComponent
literatureReference[LiteratureReference:2201278] Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
[LiteratureReference:2201318] MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
[LiteratureReference:2428888] Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
[LiteratureReference:2428798] Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
[LiteratureReference:936981] A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
modified[InstanceEdit:2206274] Shamovsky, V, 2012-04-26
[InstanceEdit:2299706] Shamovsky, V, 2012-06-01
[InstanceEdit:2428905] Shamovsky, V, 2012-08-08
[InstanceEdit:2445244] Shamovsky, V, 2012-08-13
[InstanceEdit:2559475] Shamovsky, V, 2012-11-02
[InstanceEdit:5368324] Shamovsky, V, 2014-04-28
[InstanceEdit:8959586] Weiser, JD
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
nameTIRAP:PI(4,5)P2:BTK:activated TLR2/4
MAL:PI(4,5)P2:BTK:activated TLR2/4
relatedSpecies[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2298573] R-HSA-2201331.3
(input)[Reaction:2201322] TIRAP is phosphorylated by BTK [Homo sapiens]
(output)[Reaction:2559414] Activated TLR2/4:TIRAP interacts with BTK [Homo sapiens]
(physicalEntity)[CatalystActivity:2206268] protein tyrosine kinase activity of TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]
(updatedInstance)[_UpdateTracker:9873104] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent]
[_UpdateTracker:9874304] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v43:[add_removeHasComponent, updateContainedComponent]
[_UpdateTracker:9889420] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v49:[modifyName, updateContainedComponent]
[_UpdateTracker:9891935] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v52:[updateContainedComponent]
[_UpdateTracker:9892618] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v54:[updateContainedComponent]
[_UpdateTracker:9895247] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v59:[updateContainedComponent]
[_UpdateTracker:9896786] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v60:[removeSpecies, updateContainedComponent]
[_UpdateTracker:9899498] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v66:[updateContainedComponent]
[_UpdateTracker:9899798] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v67:[updateContainedComponent]
[_UpdateTracker:9901915] Update Tracker - [Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] - v76:[updateContainedComponent]
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No pathways have been reviewed or authored by TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (2201331)
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