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Details on Person TIRAP is phosphorylated by BTK

Class:IdReaction:2201322
_displayNameTIRAP is phosphorylated by BTK
_doReleaseTRUE
_timestamp2024-02-26 21:37:43
authored[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
catalystActivity[CatalystActivity:2206268] protein tyrosine kinase activity of TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2201327] Shamovsky, V, 2012-04-19
edited[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input[Complex:2201331] TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:2201320] Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
[LiteratureReference:2201318] MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
[LiteratureReference:2201278] Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
[LiteratureReference:9863049] Structural evaluation of BTK and PKCĪ“ mediated phosphorylation of MAL at positions Tyr86 and Tyr106
modified[InstanceEdit:2206273] Shamovsky, V, 2012-04-26
[InstanceEdit:2248850] Shamovsky, V, 2012-05-15
[InstanceEdit:2248857] Shamovsky, V, 2012-05-15
[InstanceEdit:2272807] Shamovsky, V, 2012-05-25
[InstanceEdit:2272824] Shamovsky, V, 2012-05-25
[InstanceEdit:2279180] Shamovsky, V, 2012-05-28
[InstanceEdit:2559473] Shamovsky, V, 2012-11-02
[InstanceEdit:2603273] Shamovsky, V, 2012-11-19
[InstanceEdit:2627685] Shamovsky, V, 2012-11-19
[InstanceEdit:5621483] Shamovsky, V, 2014-08-29
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9615897] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9863040] Shamovsky, Veronica, 2024-02-26
nameTIRAP is phosphorylated by BTK
MAL is phosphorylated by BTK
output[Complex:2201325] activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
relatedSpecies[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate2012-06-12
reviewed[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25
[InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294782] R-HSA-2201322.4
summation[Summation:2201324] Upon activation of TLR2/or 4 signaling pathway TIRAP (MAL), ...
(hasEvent)[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(precedingEvent)[Reaction:166072] MyD88 forms a complex with TIRAP:activated TLR2/4 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779297] Update Tracker - [Reaction:2201322] TIRAP is phosphorylated by BTK - v66:[addInput, addOutput]
[_UpdateTracker:9786588] Update Tracker - [Reaction:2201322] TIRAP is phosphorylated by BTK - v49:[modifyText]
[_UpdateTracker:9864252] Update Tracker - [Reaction:2201322] TIRAP is phosphorylated by BTK - v88:[addLiteratureReference, modifyText]
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