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Details on Person Activated TLR2/4 interacts with MAL (TIRAP)

Class:Id	Reaction:2201316
_displayName	Activated TLR2/4 interacts with MAL (TIRAP)
_doRelease	TRUE
_timestamp	2020-12-01 20:15:13
authored	[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2201327] Shamovsky, V, 2012-04-19
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input	[DefinedSet:181230] Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] [Homo sapiens] [Complex:2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Homo sapiens] [Complex:2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:936981] A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors [LiteratureReference:181352] Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 [LiteratureReference:2428866] MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses
modified	[InstanceEdit:2206274] Shamovsky, V, 2012-04-26 [InstanceEdit:2248850] Shamovsky, V, 2012-05-15 [InstanceEdit:2272807] Shamovsky, V, 2012-05-25 [InstanceEdit:2272824] Shamovsky, V, 2012-05-25 [InstanceEdit:2299706] Shamovsky, V, 2012-06-01 [InstanceEdit:2559471] Shamovsky, V, 2012-11-02 [InstanceEdit:2586587] Shamovsky, V, 2012-11-15 [InstanceEdit:2603257] Shamovsky, V, 2012-11-19 [InstanceEdit:2627684] Shamovsky, V, 2012-11-19 [InstanceEdit:5621482] Shamovsky, V, 2014-08-29 [InstanceEdit:9708728] Shamovsky, Veronica, 2020-12-01 [InstanceEdit:9708846] Shamovsky, Veronica, 2020-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TLR2/4 interacts with MAL (TIRAP)
output	[Complex:2559411] TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:168951] TLR1:TLR2 is recruited to ligand:CD14 [Homo sapiens] [Reaction:2559468] TLR1/2 ligand binds to CD14 [Homo sapiens] [Reaction:168950] TLR6:TLR2 is recruited to ligand:CD14:CD36 [Homo sapiens] [Reaction:2559464] TLR6/2 ligand associates with CD14 and CD36 within lipid rafts [Homo sapiens] [Reaction:166041] Transfer of LPS onto TLR4 [Homo sapiens] [Reaction:169719] Secreted CD14 binds LPS [Homo sapiens] [Reaction:166038] GPI-bound CD14 binds LPS [Homo sapiens] [Reaction:8870678] Cleaved fibrinogen products bind TLR4:LY96 [Homo sapiens] [Reaction:5432825] HMGB1 binds TLR4:LY96 [Homo sapiens] [BlackBoxEvent:6805981] HMGB1 release from cells [Homo sapiens] [Reaction:6805943] S100A1 binds TLR4:LY96 [Homo sapiens] [Reaction:5432849] S100A8:S100A9 binds TLR4:LY96 [Homo sapiens]
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2012-06-12
reviewed	[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295283] R-HSA-2201316.3
summation	[Summation:937057] TIRAP/Mal-deficient mice showed normal responses to the TLR3...
(hasEvent)	[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:2559414] Activated TLR2/4:TIRAP interacts with BTK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788179] Update Tracker - [Reaction:2201316] Activated TLR2/4 interacts with MAL (TIRAP) - v43:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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