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Details on Person Endocytosis of TLR4:LY96:LPS:CD14

Class:Id	Reaction:2201293
_displayName	Endocytosis of TLR4:LY96:LPS:CD14
_doRelease	TRUE
_timestamp	2015-02-18 21:13:56
authored	[InstanceEdit:2201346] Shamovsky, V, 2012-04-19
compartment	[Compartment:74700] endosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:2201290] Shamovsky, V, 2012-04-19
edited	[InstanceEdit:2272804] Shamovsky, V, 2012-05-25
input	[Complex:166850] TLR4:LY96:LPS:CD14 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:975477] TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta [LiteratureReference:2201302] CD14 controls the LPS-induced endocytosis of Toll-like receptor 4 [LiteratureReference:2206252] Phospholipase C?-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation [LiteratureReference:2206254] Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells [LiteratureReference:2206238] Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
modified	[InstanceEdit:2206271] Shamovsky, V, 2012-04-26 [InstanceEdit:2248850] Shamovsky, V, 2012-05-15 [InstanceEdit:2272807] Shamovsky, V, 2012-05-25 [InstanceEdit:2272824] Shamovsky, V, 2012-05-25 [InstanceEdit:2279180] Shamovsky, V, 2012-05-28 [InstanceEdit:2581523] Shamovsky, V, 2012-11-13 [InstanceEdit:5676057] Shamovsky, Veronica, 2015-02-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Endocytosis of TLR4:LY96:LPS:CD14
output	[Complex:2201299] TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:166041] Transfer of LPS onto TLR4 [Homo sapiens] [Reaction:169719] Secreted CD14 binds LPS [Homo sapiens] [Reaction:166038] GPI-bound CD14 binds LPS [Homo sapiens]
regulatedBy	[PositiveRegulation:2201303] Positive regulation by 'Dynamin-1/2/3 [plasma membrane]' [PositiveRegulation:2201314] Positive regulation by 'PLCG2 [cytosol]'
releaseDate	2012-06-12
reviewed	[InstanceEdit:2272817] D'Eustachio, P, 2012-05-25 [InstanceEdit:2581520] Granucci, Francesca, Zanoni, Ivan, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295012] R-HSA-2201293.3
summation	[Summation:2206269] Upon LPS stimulation TLR4 is internalized into endosomes whe...
(hasEvent)	[Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade [Homo sapiens]
(precedingEvent)	[Reaction:166168] TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775094] Update Tracker - [Reaction:2201293] Endocytosis of TLR4:LY96:LPS:CD14 - v80:[add_removeRegulator] [_UpdateTracker:9788321] Update Tracker - [Reaction:2201293] Endocytosis of TLR4:LY96:LPS:CD14 - v43:[modifyText]
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