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Details on Person WIP binds WASP,N-WASP, activating them

Class:Id	Reaction:2197691
_displayName	WIP binds WASP,N-WASP, activating them
_doRelease	TRUE
_timestamp	2020-02-06 10:19:57
authored	[InstanceEdit:434636] Jupe, S, 2009-09-02
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2197699] Garapati, P V, 2012-04-13
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[Complex:442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Homo sapiens] [DefinedSet:2197679] SH3 domain proteins [cytosol] [Homo sapiens] [DefinedSet:2197678] WIP family proteins [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:204125] A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization [LiteratureReference:2197714] A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42 [LiteratureReference:2197701] CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family [LiteratureReference:203027] GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex [LiteratureReference:203036] Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway [LiteratureReference:2197689] The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor [LiteratureReference:2197692] WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation
modified	[InstanceEdit:2197715] Garapati, P V, 2012-04-13 [InstanceEdit:2248843] Garapati, P V, 2012-05-14 [InstanceEdit:2263488] Garapati, P V, 2012-05-21 [InstanceEdit:2272655] Garapati, P V, 2012-05-25 [InstanceEdit:2429700] Garapati, P V, 2012-08-09 [InstanceEdit:2457636] Garapati, P V, 2012-08-27 [InstanceEdit:3132781] Garapati, P V, 2013-02-13 [InstanceEdit:3150158] Garapati, P V, 2013-02-19 [InstanceEdit:5674559] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9667219] Murillo, Julieth, 2019-11-08 [InstanceEdit:9670158] Murillo, Julieth, 2019-12-05 [InstanceEdit:9673434] Murillo, Julieth, 2020-01-07 [InstanceEdit:9675994] Murillo, Julieth, 2020-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WIP binds WASP,N-WASP, activating them
output	[Complex:2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:442586] Activation of WASP and N-WASP by CDC42 [Homo sapiens] [BlackBoxEvent:2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP [Homo sapiens] [Reaction:9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP [Homo sapiens] [Reaction:9670156] PtdIns(4,5)P2 binds WASP, N-WASP [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200376] R-HSA-2197691.4
summation	[Summation:2197687] WASP interacting proteins (WIP) family includes WIPF1 (WIP),...
(hasEvent)	[Pathway:2029482] Regulation of actin dynamics for phagocytic cup formation [Homo sapiens] [Pathway:5663213] RHO GTPases Activate WASPs and WAVEs [Homo sapiens] [Pathway:9664422] FCGR3A-mediated phagocytosis [Homo sapiens]
(precedingEvent)	[Reaction:2197698] Src phosphorylate WASP,N-WASP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784890] Update Tracker - [Reaction:2197691] WIP binds WASP,N-WASP, activating them - v52:[modifyText]
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