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Details on Person NOTCH2 stimulates HES1 transcription

Class:Id	BlackBoxEvent:2197562
_displayName	NOTCH2 stimulates HES1 transcription
_doRelease	TRUE
_timestamp	2013-05-31 09:47:20
authored	[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2197551] Orlic-Milacic, M, 2012-04-12
edited	[InstanceEdit:3159303] Haw, R, 2013-01-14
inferredFrom	[BlackBoxEvent:2197575] Notch2 stimulates Hes1 transcription [Mus musculus]
input	[EntityWithAccessionedSequence:2197548] HES1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2197547] Functional diversity among Notch1, Notch2, and Notch3 receptors
modified	[InstanceEdit:2197583] Orlic-Milacic, M, 2012-04-12 [InstanceEdit:2976718] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:2980008] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11 [InstanceEdit:3301377] Orlic-Milacic, M, 2013-04-22 [InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3446784] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15 [InstanceEdit:3451015] Orlic-Milacic, M, 2013-05-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH2 stimulates HES1 transcription
output	[EntityWithAccessionedSequence:210825] HES1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2976716] NOTCH2 coactivator complex binds HES1 promoter [Homo sapiens] [Reaction:2197588] NICD2 binds RBPJ and MAML in the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:2197555] Positive gene expression regulation by 'NOTCH2 Coactivator Complex:HES1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642982] Positive gene expression regulation by 'NOTCH2 Coactivator Complex:HES1 gene [nucleoplasm]' Functional diversity among Notch1, Notch2, and Notch3 receptors
releaseDate	2013-06-11
reviewed	[InstanceEdit:3448657] Boyle, Scott, 2013-04-25 [InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654462] R-HSA-2197562.4
summation	[Summation:2197554] NOTCH2 coactivator complex bound to RBPJ elements in the pro...
(hasEvent)	[Pathway:2197563] NOTCH2 intracellular domain regulates transcription [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH2 stimulates HES1 transcription (2197562)